As a result, Aaron Ramsdale will come in for his first Premier League start since September's victory over Manchester United and will attempt to replicate his man-of-the-match showing in a 1-0 EFL Cup win over Brentford two months ago, where he produced a number of crucial stops.
In addition to Raya, Fabio Vieira is beginning a three-game ban for his sending off against Burnley, while Emile Smith Rowe (knee), Jurrien Timber (knee) and Thomas Partey (thigh) are not at Arteta's disposal either.
Ben White is one of a few players on the doubtful list due to a knock, but the reborn Takehiro Tomiyasu and Oleksandr Zinchenko - who scored a sumptuous scissor kick against Burnley - do not deserve to be demoted.
William Saliba's spot in defence is not under any threat, although Arteta may consider bringing Jakub Kiwior into the fray if Gabriel Magalhaes needs more time to recover from his exploits in South America, but there is nothing to suggest that the Brazilian will not be involved here.
Declan Rice and Jorginho appear to be shoo-ins in midfield, but with Martin Odegaard on track to recover from a head injury in time for the derby, Kai Havertz - who was peculiarly deployed as a left-back for Germany this month - could drop out.
Gabriel Jesus joined up with the Brazil squad against Arsenal's wishes, but the call-up proved to benefit all parties, as the striker was able to complete the full 90 minutes in a 1-0 loss to Argentina.
Jesus will surely only be considered for a place on the bench here, though, as Leandro Trossard continues to lead the line with support from Bukayo Saka and Gabriel Martinelli, although Eddie Nketiah can cover for the latter if need be.
Arsenal possible starting lineup: Ramsdale; Tomiyasu, Saliba, Gabriel, Zinchenko; Odegaard, Jorginho, Rice; Saka, Trossard, MartinelliNo Data Analysis info